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Comparison of CNS lesions on axial FLAIR MRI before and after chenodeoxycholic acid therapy

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FLAIR sequence shows bilaterally symmetrical hyperintensity in the cerebellar white matter and the dentate nucleus (arrowhead). The left image was taken before therapy, and the right image after 9 months of chenodeoxycholic acid therapy. The images show that there has been no progression of lesion growth. (Source: Brlek P, Bulić L, Glavaš Weinberger D, et al. Successful treatment of a rare cholesterol homeostasis disorder due to CYP27A1 gene mutation with chenodeoxycholic acid therapy. Biomedicines 2023;11[5]:1430. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)