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Vulnerability of periventricular region to LCMV infection

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The periventricular region is selectively vulnerable to LCMV infection and pathology in the human fetus and in the developing rat. [A] This head CT scan from an infant with congenital LCMV infection reveals microencephaly and periventricular calcifications (arrows). [B] Fifty-micrometer-thick horizontal section through a 49-day-old rat brain immunohistochemically stained for LCMV. The rat was inoculated as a neonate with LCMV. Infection is localized to the periventricular region (arrows). L = lateral ventricle, S = septum, BG = basal ganglia. [C] Higher magnification of the boxed area in panel [B] shows that the infected cells are neuronal in morphology. Viral antigen is present in neuronal cell bodies (arrows) and neurites (arrowheads). Magnification bars represent 500 um in B and 100 um in C. (Part of this figure is reproduced from Bonthius and Perlman, PLoS Pathogens 2007; 3:1541-50.)