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Cerebellar cortical hypertrophy (photomicrograph)

The lesion of the cerebellar cortex at low magnification shows enlarged, vacuolated molecular layer and hypertrophic cells replacing the Purkinje and granule cell layers. This architecture gives the lesion the gross appearance, both by imaging and pathologically, of thickened folia. (Hematoxylin-eosin; x100) (Contributed by Dr. Laura Hair.)

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Associated Disorders

  • Bannayan-Riley-Ruvalcaba syndrome
  • COLD syndrome
  • Cowden disease
  • Cowden syndrome
  • PTEN hamartoma tumor syndrome