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MiB-1 immunostaining of a pituitary adenoma from a 22-year-old man with acromegaly

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(x 200) The proliferation index is very low with approximately 3% of cells showing immunoreactivity against MiB-1. The MIB-1 monoclonal antibody recognizes the Ki-67 protein, which is expressed over the entire cell cycle except for the G0 phase; it has been used as an operational marker of cell proliferation for various types of tumors. (Source: Gosau M, Vogel C, Moralis A, Proff P, Kleinheinz J, Driemel O. Mandibular prognathism caused by acromegaly - a surgical orthodontic case. Head Face Med 2009;5:16. Creative Commons Attribution 2.0 License, creativecommons.org/licenses/by/2.0. Figure edited by Dr. Douglas J Lanska to improve detail and contrast.)