General Neurology
Hypoparathyroidism
May. 14, 2024
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Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
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For pyruvate dehydrogenase (R=H). For alpha-ketoglurate (R=CH2-COO-). Step A is the E1k-mediated decarboxylation step, utilizing TPP as a cofactor. Steps B and C are E2k-mediated sequential succinylation steps, ultimately forming succinyl CoA and utilizing lipoamide and coenzyme A as cofactors. Steps D and E are E3-mediated electron transfer reactions that utilize FAD and NAD as cofactors. (Courtesy of Wikimedia Commons. Public domain.)