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French physiologist Claude Bernard (1813-1878) showed that carbon monoxide produces hypoxia by reversible combination with hemoglobin

Lithograph by Alexandre Laemlein (1813-1871). (Source: Bibliothèque interuniversitaire de Santé, Paris. Licence Ouverte 1.0, https://en.wikisource.org/wiki/Open_Licence_v1.0. Illustration restored by Dr. Douglas J Lanska.)

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