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Photomicrographs of frozen skin sections (50 μm) from a patient with Fabry disease

Samples immunoreacted with PGP 9.5 and were processed for fluorescence microscopy with Cy3 labeled secondary antibodies. Note the lack of intraepidermal nerve fibers and persistence of fibers pertaining to the subepidermal nerve plexus (arrows) in the sample from the lower leg skin of a patient with Fabry disease (upper figure). Note the dense innervation of the epidermis (arrows) in the sample from the back of the patient with Fabry disease, taken at the T12 dermatome (lower figure). Bar = 50 μm. (Source: Burlina AP, Sims KB, Politei JM, et al. Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel. BMC Neurol 2011;11:61.)

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