Movement Disorders
Limb dystonia
Jun. 07, 2023
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Schematic location and functioning of cellular folate transporters FRα and PCFT in the transcytosis of folate in the renal tubular epithelium
Schematic location and functioning of cellular folate transporters FRα and PCFT in the transcytosis of folate in the renal tubular epithelium}{label:Renal reabsorption of folates from glomerular filtrate in the proximal tubules relies on the high-affinity folate receptor FRα through a process of transcytosis. In the diagram, the apical surface of polarized renal tubular epithelial cells is marked by an irregular contour.
Legend: FRα: folate receptor alpha; PCFT: proton-coupled folate transporter. (Source: Shulpekova Y, Nechaev V, Kardasheva S, et al. The concept of folic acid in health and disease. Molecules 2021;26(12):3731.) (Modified by Dr. Douglas Lanska. Creative Commons Attribution 4.0 [CC BY] license.)