Epilepsy & Seizures
Mitochondrial epilepsy
Jan. 03, 2024
This is an image preview.
Start a Free Account
to view the full image.
-
Nearly 3,000 illustrations, including video clips of neurologic disorders.
-
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
-
Full spectrum of neurology in 1,200 comprehensive articles.
-
Listen to MedLink on the go with Audio versions of each article.
RFC functions on the basolateral membranes of the renal tubular epithelium to transport 5-methyl-THF
The folate-specific transporters reduced folate carrier (RFC) and proton-coupled folate transported (PCFT) are highly expressed in the proximal renal tubule, with known expression of RFC at the basolateral membrane, although RFC may also be present at the apical membrane. RFC function to bring 5-methyl-THF from the blood into the renal tubular epithelium to support intracellular metabolism and from the renal tubular epithelium to the blood to facilitate renal reabsorption of folate. The direction of transfer depends on the amount of available folate in the various compartments. (Source: Shulpekova Y, Nechaev V, Kardasheva S, et al. The concept of folic acid in health and disease. Molecules 2021;26(12):3731.) (Modified by Dr. Douglas Lanska. Creative Commons Attribution 4.0 [CC BY] license.)