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MRI pattern A1 (early-infantile Krabbe disease) (2)

Cerebellar changes in an early infantile patient during the disease course (onset 4 months). The T2-weighted axial MRI at age 5.5 months shows hyperintensity in the dentate nucleus (a), which had disappeared 8 months later (b). (Source: Krieg SI, Krägeloh-Mann I, Groeschel S, et al. Natural history of Krabbe disease: a nationwide study in Germany using clinical and MRI data. Orphanet J Rare Dis 2020;15[1]:243. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)

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  • Adult globoid cell leukodystrophy
  • Diffuse brain-sclerosis
  • Diffuse gliosis
  • Early infantile globoid cell leukodystrophy
  • Juvenile globoid cell leukodystrophy
  • Late infantile globoid cell leukodystrophy
  • Leukodystrophy