Infectious Disorders
Creutzfeldt-Jakob disease
Feb. 12, 2024
This is an image preview.
Start a Free Account
to view the full image.
-
Nearly 3,000 illustrations, including video clips of neurologic disorders.
-
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
-
Full spectrum of neurology in 1,200 comprehensive articles.
-
Listen to MedLink on the go with Audio versions of each article.
Reactive oxygen species clearance
Superoxide dismutases convert superoxide enzymatically into hydrogen peroxide, which can be converted into water either by the enzyme catalase or the enzyme glutathione peroxidase. In the glutathione peroxidase reaction, glutathione is oxidized to glutathione disulfide. Glutathione disulfide can be converted back to glutathione by glutathione reductase, in a reaction that consumes NADPH. Legend: H2O = water; H2O2 = hydrogen peroxide; O2 = oxygen molecule; O2.- = superoxide; GSH = glutathione; GSSH = glutathione disulfide (oxidized form of glutathione); NADP+ = nicotinamide adenine dinucleotide phosphate; NADPH = nicotinamide adenine dinucleotide phosphate (reduced form). (Contributed by Dr. Douglas Lanska.)