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Binding of N. meningitidis to epithelial cells

Binding of N meningitidis to epithelial cells occurs by interaction of bacterial surface structures with their cognate receptors, resulting in inflammation, cellular restructuring, and transcytosis. (Source: Mikucki A, McCluskey NR, Kahler CM. The host-pathogen interactions and epicellular lifestyle of Neisseria meningitidis. Front Cell Infect Microbiol 2022;12:862935. Creative Commons Attribution 4.0 International License, http://creativecommons.org/licenses/by/4.0.)

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  • asplenia
  • deficiency of a terminal complement component (C5-9)
  • deficiency of properdin