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Scheme of complexes of the Pt(NH3)2(OH)+ moiety of carboplatin with the B vitamins

Scheme of complexes of the Pt(NH3)2(OH)+ moiety of carboplatin with the B vitamins, including vitamin B6 (pyridoxine, or its active form pyridoxal 5'-phosphate). The only vitamin with a positive charge is thiamine (vitamin B1). Note that the chemical symbol of platinum is Pt. (Source: Szefler B, Czeleń P, Krawczyk P. The affinity of carboplatin to B-vitamins and nucleobases. Int J Mol Sci 2021;22[7]:3634. Creative Commons Attribution License [CC BY], creativecommons.org/licenses/by/4.0.)

Associated Disorders

  • Vitamin deficiency and toxicity