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Family pedigree of a patient with Fabry disease showing the x-linked pattern of inheritance (3)

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The index patient (propositus) is marked with a black arrow. Affected males are indicated by solid black squares; female carriers are indicated by a round black circle within the larger circle denoting a woman. Numbers within symbols denote the number of male or female relatives; a question mark denotes subjects unavailable for biochemical and genetic evaluation due to refusal or death. Note how the disease appears to "skip" a generation in which both children were girls. (Source: Cianci V, Pascarella A, Manzo L, et al. Late-onset Fabry disease due to the p.Phe113Leu variant: the first Italian cluster of five families. Metab Brain Dis 2023;38[6]:1905-12. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)