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Molecular pathways underlying noise-induced hearing loss and potential therapeutic opportunities

Signaling pathways involved in (A) inflammation, (B) energy metabolism, (C) oxidative stress, (D) programmed cell death, and (E) excitotoxicity and autophagy are illustrated in separated regions. Protective responses are shown in green. Adverse cellular events are shown in red. Pharmacological interventions are shown in purple. (Source: Xu K, Xu B, Gu J, Wang X, Yu D, Chen Y. Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss. Theranostics 2023;13[11]:3524-9. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)

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