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NORSE treatment algorithm: commonly used drugs in NORSE with most frequently reported doses (expert opinion)

Legend: c-NORSE, cryptogenic NORSE; IV, intravenous; IVIG, intravenous immunoglobulin; RSE refractory status epilepticus; SE, status epilepticus; SC, subcutaneous.

Adapted from:
Wickstrom R, Taraschenko O, Dilena R, et al. International consensus recommendations for management of new onset refractory status epilepticus (NORSE) incl. febrile infection-related epilepsy syndrome (FIRES): statements and supporting evidence. Epilepsia 2022;63(11):2840-64.

Hanin A, Jimenez AD, Gopaul M, Asbell H, et al. Trends in management of patients with new-onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis. Epilepsia. 2024 Aug;65(8):e148-e155.

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Associated Disorders

  • Genetic encephalopathy
  • Infectious encephalitis
  • Paraneoplastic encephalitis
  • Postinfectious disorders
  • Primary autoimmune encephalitis