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Flow chart of a stepwise workup of neonatal seizures and status epilepticus

Include lactate reading on blood gas; CRP: C-reactive protein; U&E: urea and electrolytes; LFTs: liver function tests; CSF: cerebrospinal fluid; PCR: polymerase chain reaction test; CT: computed tomography; MRI: magnetic resonance imaging; aEEG: amplitude-integrated EEG; TORCH: Toxoplasmosis, Rubella, Cytomegalovirus, and Herpes simplex virus; DNA: deoxyribonucleic acid. (Contributed by Dr. Ronit Pressler.)

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Associated Disorders

  • acute metabolic disturbances
  • cerebral infections
  • early infantile developmental and epileptic encephalopathies
  • epilepsy of infancy with migrating focal seizures
  • hypoxic-ischemic encephalopathy
  • self-limited (familial) neonatal epilepsy
  • self-limited (familial) neonatal-infantile epilepsy
  • vascular insults