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Tissue block in fetus with hypertelorism

Left schematic drawing and right histological sagittal paraffin section of a tissue block from the sella turcica region in a human fetus with hypertelorism and nasal malformation. Anterior direction is left. Note the absence of a normal sella turcica morphology and the presence of a broad canal in the cranial base between the cartilage primordium of the sphenoid bone (left) and the occipital bone (right). Adenopituitary gland tissue appears as a polyp-like cell mass extending from the pharyngeal mucosa into the pharyngeal cavity. No neurohypophysis is seen. Toluidine blue. (Reproduced with permission. J Craniofac Genet Dev Biol 1995;15:222-9.)

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Associated Disorders

  • Anencephaly
  • CHARGE syndrome
  • Cleft lip and palate
  • Duplication of pituitary stalk
  • Ectopic neurohypophysis
  • Empty sella syndrome
  • Holoprosencephaly
  • Hypertelorism
  • Midfacial anomalies
  • Myelomeningocele
  • Pallister-Hall syndrome
  • Pituitary agenesis
  • Pituitary aplasia
  • Pituitary dysplasia
  • Pituitary ectopia
  • Pituitary hypoplasia
  • Rachischisis
  • Rathke cleft cyst
  • Rieger syndrome
  • Rubinstein-Taybi syndrome
  • Septo-optic dysplasia
  • Solitary maxillary central incisor
  • Spina bifida